Biko Paris and Reggie Jackson combined for 29 points in the first half, and Boston College holds a commanding 16-point halftime lead over Wake Forest.
Paris scored 15 points on 5 of 7 from three-point range, and Jackson shot 6 of 7 from the field to add 14.
The Eagles shot 58.1 percent in the first half and 52.9 percent from beyond the arc.
Travis McKie scored Wake Forest's first nine points and had 13 total in the first half.
Boston College is winning the rebounding battle, 23-11.